Have you ever wondered why antidepressants are so slow to work? When receiving a new prescription for a drug designed to treat depression, anxiety, and other mood disorders, patients are often told that they can expect to wait several weeks or even a few months before their new medications begin working properly. Even hospital settings struggle to see appreciable results with emergency-strength doses of these drugs in patients who are committed. But why?
The answer may be linked to faulty communication and signaling on the part of G proteins. This is why treatments for depression are increasingly targeting these proteins to enable faster, better symptom relief and management of mood disorders. Here’s more of what you need to know about today’s changing approaches for treating these conditions from the root cause, rather than just addressing symptoms:
All Aboard the Lipid Raft
If you’ve ever seen a vehicle become stuck in a mud puddle or slow down and stop due to high water, you’ve witnessed something very similar to what scientists now believe causes the numb, detached feeling that depression sufferers cope with. Signaling molecules that are present in membranes called G proteins are thought to be important in the communication and transportation of antidepressant drugs to the rest of the brain. These molecules tend to congregate and become trapped in areas of the membrane that are higher in cholesterol. These so-called “lipid rafts” keep these molecules from having access to the cyclic adenosine monophosphate that both allows them to function normally and which enables them to distribute the serotonin-boosting properties of the medications these patients take to combat their depression. When the molecules can’t access this substance, they can’t work properly, and signals are dampened, leading to the symptoms of depression and other mood disorders – and the extremely slow action of the drugs used to address them.
How Ketamine Addresses Inactive G Proteins
The use of ketamine as a depression treatment has been employed in depression recovery centers in Phoenix and other areas for several years now. Facilities like Ketamine Infusion Centers have been using the results of recent research to treat the collection of signaling molecules on the lipid rafts of G proteins, thereby addressing the root issue that causes many of the signs and symptoms of depression. This enables the brain to return to normal function faster and gives the drugs often prescribed for the treatment of depression a fighting chance to do their job. Thus, ketamine is providing a different approach to the treatment of depression – and a better, brighter, and more promising tomorrow for those currently coping with it.