Treatment Resistant

There is a wide range of effective, evidence-based, biological, and psychotherapeutic treatments for people with depression, anxiety, schizophrenia, etc. However, some people who receive medications and psychotherapy are not able to become fully functioning. Despite trying several treatments, they may show improvement, but still be unable to work, attend school, or function adequately in society. Faced with long-term depression or anxiety, these treatment resistant patients may end up suffering from comorbid disorders, such as mood and anxiety disorders, substance use disorders, eating disorders, PTSD, etc.

There are a variety of different medications that are used to treat mood and anxiety disorders. The idea is to alter the brain chemistry to function properly. Different medications affect different brain functions, that is why a variety of anti-depressants and other medications are attempted, to try to find something that works. For treatment resistant patients, none of them seem to be successful in fully relieving their symptoms.

An imbalance between glutamate (neurotransmitters in the brain that influences the formation and number of brain synapses), and GABA (gamma-aminobutyric acid, an inhibitory neurotransmitter), is associated with depression, anxiety, and other mood disorders. A solution that seems to help treatment resistant patients is Ketamine infusion therapy. Ketamine balances the glutamate system by binding to the NMDA receptor and blocking glutamate from binding on the cell membranes, creating an increase of glutamate which causes a cascade of neurobiological events resulting in rapid antidepressant effects.

Ketamine also impacts the mTOR pathway, which regulates cell growth among other things, and the AMPA receptor which mediates synaptic transmission in the central nervous system. Ketamine impacts these pathways and drives the growth of new neural connections and increases neuroplasticity, which is the ability of the brain to adapt and change. This is how Ketamine helps with depression, anxiety, PTSD, and other mood disorders.

For patients who have tried multiple anti-depressants and other treatments for their mood or anxiety disorders with no results, Ketamine infusion therapy may be the answer to help them enjoy life. Contact Ketamine Infusion Centers today to get started on your road to long-term relief from the symptoms of depression, anxiety, and other mood disorders.

2020-06-18T14:57:34-07:00 June 18th, 2020|